首页> Molecular metabolism> PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes.

PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes.

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第一作者： Jiefu,Wang

第一单位： RG Adipocytes & Metabolism, Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764, Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.

作者： Jiefu,Wang ^[1] ; Yasuhiro,Onogi ^[1] ; Martin,Krueger ^[2] ; Josef,Oeckl ^[3] ; Ruth,Karlina ^[1] ; Inderjeet,Singh ^[1] ; Stefanie M,Hauck ^[4] ; Regina,Feederle ^[5] ; Yongguo,Li ^[3] ; Siegfried,Ussar ^[6]

作者单位： RG Adipocytes & Metabolism, Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764, Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany. ^[1] Institute for Anatomy, University of Leipzig, 04103, Leipzig, Germany. ^[2] Chair for Molecular Nutritional Medicine TUM School for Life Sciences,Technical University Munich, Munich, Germany. ^[3] German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany; Research Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany. ^[4] German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany; Monoclonal Antibody Core Facility, Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764, Neuherberg, Germany. ^[5] RG Adipocytes & Metabolism, Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764, Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany; Department of Medicine, Technische Universität München, Munich, Germany. Electronic address: siegfried.ussar@helmholtz-munich.de. ^[6]

关键词 Brown adipocytes Lysosomal acidification Proton-coupled amino acid transporter Transporter translocation across membranes V-ATPase assembly

医学主题词脂肪细胞, 棕色(Adipocytes, Brown);氨基酸类(Amino Acids);内环境稳定(Homeostasis);氢离子浓度(Hydrogen-Ion Concentration);溶酶体(Lysosomes)

DOI 10.1016/j.molmet.2022.101508

PMID 35513259

发布时间 2022-07-28

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