AR cooperates with SMAD4 to maintain skeletal muscle homeostasis.

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作者： Mitra,Forouhan ^[1] ; Wooi Fang,Lim ^[1] ; Laura C,Zanetti-Domingues ^[2] ; Christopher J,Tynan ^[2] ; Thomas C,Roberts ^[1] ; Bilal,Malik ^[3] ; Raquel,Manzano ^[4] ; Alfina A,Speciale ^[1] ; Ruth,Ellerington ^[1] ; Antonio,Garcia-Guerra ^[1] ; Pietro,Fratta ^[3] ; Gianni,Sorarú ^[5] ; Linda,Greensmith ^[6] ; Maria,Pennuto ^[3] ; Matthew J A,Wood ^[6] ; Carlo,Rinaldi ^[7]

作者单位： Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK. ^[1] Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Didcot, Oxfordshire, UK. ^[2] Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK. ^[3] Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. ^[4] Department of Neurosciences, Neurology Unit, University of Padova, Padova, Italy. ^[5] Venetian Institute of Molecular Medicine (VIMM), Padova, Italy. ^[6] Department of Biomedical Sciences, University of Padova, Padova, Italy. ^[7] MDUK Oxford Neuromuscular Centre, University of Oxford, Oxford, UK. ^[8] Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK. carlo.rinaldi@paediatrics.ox.ac.uk. ^[9] MDUK Oxford Neuromuscular Centre, University of Oxford, Oxford, UK. carlo.rinaldi@paediatrics.ox.ac.uk. ^[10]

关键词 Androgen receptor Androgens Muscle atrophy SBMA TGFβ pathway Transcriptional cooperativity