Genome-wide analyses of PAM-relaxed Cas9 genome editors reveal substantial off-target effects by ABE8e in rice.

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作者： Yuechao,Wu ^[1] ; Qiurong,Ren ^[2] ; Zhaohui,Zhong ^[3] ; Guanqing,Liu ^[4] ; Yangshuo,Han ^[4] ; Yu,Bao ^[1] ; Li,Liu ^[2] ; Shuyue,Xiang ^[3] ; Shuo,Liu ^[1] ; Xu,Tang ^[2] ; Jianping,Zhou ^[3] ; Xuelian,Zheng ^[1] ; Simon,Sretenovic ^[2] ; Tao,Zhang ^[3] ; Yiping,Qi ^[4] ; Yong,Zhang ^[4]

作者单位： Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Jiangsu Key Laboratory of Crop Genetics and Physiology, Agricultural College of Yangzhou University, Yangzhou, China. ^[1] Key Laboratory of Plant Functional Genomics of the Ministry of Education/Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, China. ^[2] Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Yangzhou University, Yangzhou, China. ^[3] Department of Biotechnology, School of Life Sciences and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China. ^[4] Department of Plant Science and Landscape Architecture, University of Maryland, College Park, Maryland, USA. ^[5] Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, USA. ^[6]

关键词 PAM-relaxed Cas9 nucleases adenine base editor cytosine base editor genome editing off-target effect rice whole-genome sequencing

主题词内切核酸酶类(Endonucleases);全基因组关联研究(Genome-Wide Association Study);植物, 基因修饰(Plants, Genetically Modified)

DOI 10.1111/pbi.13838

PMID 35524459

发布时间 2024-02-21

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