首页> Molecular therapy : the journal of the American Society of Gene Therapy> Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen.

Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen.

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第一作者： Zaid,Taha

第一单位： Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

作者： Zaid,Taha ^[1] ; Rozanne,Arulanandam ^[2] ; Glib,Maznyi ^[2] ; Elena,Godbout ^[2] ; Madalina E,Carter-Timofte ^[3] ; Naziia,Kurmasheva ^[3] ; Line S,Reinert ^[3] ; Andrew,Chen ^[2] ; Mathieu J F,Crupi ^[2] ; Stephen,Boulton ^[2] ; Geneviève,Laroche ^[4] ; Alexandra,Phan ^[4] ; Reza,Rezaei ^[1] ; Nouf,Alluqmani ^[1] ; Anna,Jirovec ^[1] ; Alexandra,Acal ^[2] ; Emily E F,Fekete ^[2] ; Ragunath,Singaravelu ^[2] ; Julia,Petryk ^[2] ; Manja,Idorn ^[3] ; Kyle G,Potts ^[5] ; Hayley,Todesco ^[5] ; Cini,John ^[5] ; Douglas J,Mahoney ^[5] ; Carolina S,Ilkow ^[1] ; Patrick,Giguère ^[4] ; Tommy,Alain ^[6] ; Marceline,Côté ^[4] ; Søren R,Paludan ^[3] ; David,Olagnier ^[3] ; John C,Bell ^[1] ; Taha,Azad ^[2] ; Jean-Simon,Diallo ^[7]

作者单位： Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[1] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. ^[2] Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. ^[3] Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[4] Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. ^[5] Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. ^[6] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: jsdiallo@ohri.ca. ^[7]

关键词 COVID-19 SARS-CoV-2 bifonazole drug discovery high-throughput screening nanoluciferase bioreporter

医学主题词动物(Animals);抗病毒药(Antiviral Agents);咪唑类(Imidazoles);小鼠(Mice);蛋白质结合(Protein Binding);美国(United States);美国食品和药物管理局(United States Food and Drug Administration)

DOI 10.1016/j.ymthe.2022.04.025

PMID 35526097

发布时间 2023-02-23

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