Chemical characteristics of Rhodiola Crenulata and its mechanism in acute mountain sickness using UHPLC-Q-TOF-MS/MS combined with network pharmacology analysis.

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第一作者： Didi,Ma

第一单位： School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China; Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China; NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China; Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China.

作者： Didi,Ma ^[1] ; Lijun,Wang ^[2] ; Yibao,Jin ^[2] ; Lifei,Gu ^[2] ; Guo,Yin ^[2] ; Jue,Wang ^[2] ; Xie-An,Yu ^[2] ; Houshuang,Huang ^[2] ; Zhen,Zhang ^[2] ; Bing,Wang ^[2] ; Yi,Lu ^[2] ; Kaishun,Bi ^[3] ; Ping,Wang ^[2] ; Tiejie,Wang ^[4]

作者单位： School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China; Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China; NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China; Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China. ^[1] Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China; NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China; Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China. ^[2] School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China. ^[3] School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China; Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China; NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China; Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control, Shenzhen, Guangdong, 518057, China. Electronic address: szyjwtj@163.com. ^[4]

关键词 Acute mountain sickness Experimental verification Molecular docking Network pharmacology Rhodiola crenulata UHPLC-Q-TOF-MS/MS