Peroxidase from foxtail millet bran exerts anti-colorectal cancer activity <i>via</i> targeting cell-surface GRP78 to inactivate STAT3 pathway.
第一作者:
Shuhua,Shan
第一单位:
Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China.
作者:
关键词
CAC, colitis-associated carcinogenesisCDKs, cyclin-dependent kinasesCETSA, cellular thermal shift assayCRC, colorectal cancerCo-IP, co-immunoprecipitationColorectal cancerDCFH-DA, dichloro-dihydro-fluorescein diacetateEGFR, epidermal growth factor receptorER, endoplasmic reticulumFDA, U.S. Food and Drug AdministrationFMBPFMBP, peroxidase derived from foxtail millet branFoxtail millet branGRP78, glucose-regulated protein 78H&E, hematoxylin & eosinISM, isthminMPs, membrane proteinsNBD, the nucleotide binding domain of csGRP78PD-1, programmed death-1ROSROS, reactive oxygen speciesSBD, substrate-binding domain of csGRP78SPF, specific pathogen freeSTAT3STAT3, signal transducer and activator of transcription 3TRAIL, tumor necrosis factor-related apoptosis-inducing ligandcsGRP78csGRP78, cell surface glucose-regulated protein 78rGRP78, recombinant GRP78
DOI
10.1016/j.apsb.2021.10.004
PMID
35530132
发布时间
2022-07-16
- 浏览6
Acta pharmaceutica Sinica. B
2022年12卷3期
1254-1270页
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