Identification and Strategies to Mitigate High Total Clearance of Benzylamine-Substituted Biphenyl Ring Systems.

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第一作者： Beth,Williamson

第一单位： Drug Metabolism and Pharmacokinetics, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.

作者： Beth,Williamson ^[1] ; Lindsay,McMurray ^[2] ; Scott,Boyd ^[2] ; Olga,Collingwood ^[2] ; Neville,McLean ^[2] ; Jon,Winter-Holt ^[2] ; Christina,Chan ^[1] ; Aixiang,Xue ^[3] ; William,McCoull ^[2]

作者单位： Drug Metabolism and Pharmacokinetics, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK. ^[1] Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK. ^[2] R&D Clinical Pharmacology and Safety Sciences, AstraZeneca, Waltham 02451, United States. ^[3]

关键词 DMPK IVIVE benzylamine clearance

主题词动物(Animals);苄胺类(Benzylamines);联苯化合物(Biphenyl Compounds);肝细胞(Hepatocytes);代谢清除率(Metabolic Clearance Rate);模型, 生物学(Models, Biological);大鼠(Rats)

DOI 10.1021/acs.molpharmaceut.2c00014

PMID 35533086

发布时间 2022-07-13

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