Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.

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第一作者： Raquel N,Taddei

第一单位： Department of Neurology, Massachusetts General Hospital, 15th Parkman St, Boston, MA, 02114, USA.;Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA.;Department of Neurology, Dementia Research Institute, University College London, London, UK.

作者： Raquel N,Taddei ^[1] ; Maria V,Sanchez-Mico ^[2] ; Orla,Bonnar ^[2] ; Theresa,Connors ^[3] ; Angelica,Gaona ^[3] ; Dominique,Denbow ^[2] ; Matthew P,Frosch ^[3] ; Teresa,Gómez-Isla ^[4]

作者单位： Department of Neurology, Massachusetts General Hospital, 15th Parkman St, Boston, MA, 02114, USA.;Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA.;Department of Neurology, Dementia Research Institute, University College London, London, UK. ^[1] Department of Neurology, Massachusetts General Hospital, 15th Parkman St, Boston, MA, 02114, USA. ^[2] Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA.;C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA, USA. ^[3] Department of Neurology, Massachusetts General Hospital, 15th Parkman St, Boston, MA, 02114, USA. tgomezisla@mgh.harvard.edu.;Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA. tgomezisla@mgh.harvard.edu. ^[4]

关键词 AD Cognition Cortical cell vulnerability Glial phenotypes Neurofibrillary tangles White matter changes

主题词老年人(Aged);阿尔茨海默病(Alzheimer Disease);脑(Brain);认知(Cognition);人类(Humans);神经原纤维缠结(Neurofibrillary Tangles);神经胶质(Neuroglia);表型(Phenotype);斑块, 淀粉样(Plaque, Amyloid);tau蛋白质类(tau Proteins)

DOI 10.1186/s40478-022-01370-3

PMID 35534858

发布时间 2024-08-27

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Acta neuropathologica communications

2022年10卷1期

72页

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Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.

Acta neuropathologica communications

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Acta neuropathologica communications

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Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.

Acta neuropathologica communications

相似文献

Acta neuropathologica communications

相关期刊

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