An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy.

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作者： Pasquale,Sibilio ^[1] ; Francesca,Belardinilli ^[2] ; Valerio,Licursi ^[3] ; Paola,Paci ^[4] ; Giuseppe,Giannini ^[5]

作者单位： Department of Translational and Precision Medicine, University La Sapienza, 00161, Rome, Italy. ^[1] Institute for Systems Analysis and Computer Science Antonio Ruberti, National Research Council, 00185, Rome, Italy. ^[2] Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy. ^[3] Department of Biology and Biotechnologies "Charles Darwin", University La Sapienza, 00185, Rome, Italy. ^[4] Institute of Molecular Biology and Pathology, National Research Council of Italy, Via degli Apuli, 4, 00185, Rome, Italy. ^[5] Department of Computer Engineering, Automation and Management, University La Sapienza, 00161, Rome, Italy. ^[6] Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy. giuseppe.giannini@uniroma1.it. ^[7] Istituto Pasteur-Fondazione Cenci Bolognetti, 00161, Rome, Italy. giuseppe.giannini@uniroma1.it. ^[8]

关键词 Colorectal cancer Immunoinformatics Immunotherapy Meta-analysis Multi-omics

主题词染色体不稳定性(Chromosomal Instability);结直肠肿瘤(Colorectal Neoplasms);DNA拷贝数变异(DNA Copy Number Variations);人类(Humans);免疫疗法(Immunotherapy);微卫星不稳定性(Microsatellite Instability);肿瘤微环境(Tumor Microenvironment)

DOI 10.1186/s13062-022-00324-y

PMID 35534873

发布时间 2022-07-16

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