Refining colorectal cancer classification and clinical stratification through a single-cell atlas.

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第一作者： Ateeq M,Khaliq

第一单位： Indiana University School of Medicine, Indianapolis, IN, USA.

作者： Ateeq M,Khaliq ^[1] ; Cihat,Erdogan ^[2] ; Zeyneb,Kurt ^[3] ; Sultan Sevgi,Turgut ^[4] ; Miles W,Grunvald ^[5] ; Tim,Rand ^[6] ; Sonal,Khare ^[6] ; Jeffrey A,Borgia ^[5] ; Dana M,Hayden ^[5] ; Sam G,Pappas ^[5] ; Henry R,Govekar ^[5] ; Audrey E,Kam ^[5] ; Jochen,Reiser ^[5] ; Kiran,Turaga ^[7] ; Milan,Radovich ^[1] ; Yong,Zang ^[1] ; Yingjie,Qiu ^[1] ; Yunlong,Liu ^[1] ; Melissa L,Fishel ^[1] ; Anita,Turk ^[1] ; Vineet,Gupta ^[5] ; Ram,Al-Sabti ^[5] ; Janakiraman,Subramanian ^[8] ; Timothy M,Kuzel ^[5] ; Anguraj,Sadanandam ^[9] ; Levi,Waldron ^[10] ; Arif,Hussain ^[11] ; Mohammad,Saleem ^[5] ; Bassel,El-Rayes ^[12] ; Ameen A,Salahudeen ^[6] ; Ashiq,Masood ^[13]

作者单位： Indiana University School of Medicine, Indianapolis, IN, USA. ^[1] Isparta University of Applied Sciences, Isparta, Turkey. ^[2] Northumbria University, Newcastle Upon Tyne, UK. ^[3] Yildiz Technical University, Istanbul, Turkey. ^[4] Rush University Medical Center, Chicago, IL, USA. ^[5] Tempus Labs, Inc., Chicago, IL, USA. ^[6] The University of Chicago, Chicago, IL, USA. ^[7] Inova Schar Cancer Institute, Fairfax, VA, USA. ^[8] Institute of Cancer Research, London, UK. ^[9] CUNY Graduate School of Public Health and Health Policy, New York, NY, USA. ^[10] University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA. ^[11] University of Alabama, O'Neil Comprehensive Cancer Institute, Birmingham, AL, USA. ^[12] Indiana University School of Medicine, Indianapolis, IN, USA. asmasood@iu.edu. ^[13]

关键词 CMS classification Cancer-associated fibroblast Colorectal cancer Immunotherapy Single-cell analysis Stromal signatures

主题词结直肠肿瘤(Colorectal Neoplasms);补体C1q(Complement C1q);人类(Humans);微卫星不稳定性(Microsatellite Instability);肿瘤微环境(Tumor Microenvironment)

DOI 10.1186/s13059-022-02677-z

PMID 35538548

发布时间 2023-08-31

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准确一般字义偏差语意偏离译文作用小提交