Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia.

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作者： Sharmelee,Selvaraji ^[1] ; Motakis,Efthymios ^[2] ; Roger Sik Yin,Foo ^[3] ; David Y,Fann ^[4] ; Mitchell Kim Peng,Lai ^[5] ; Christopher Li Hsian,Chen ^[3] ; Kah Leong,Lim ^[4] ; Thiruma V,Arumugam ^[5]

作者单位： Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ^[1] Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore. ^[2] Cardiovascular Research Institute, National University Health System, Singapore. ^[3] Cardiovascular Translational Research Programme, National University of Singapore, Singapore. ^[4] Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore. ^[5] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ^[6] Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ^[7] Centre for Healthy Longevity, National University Health System (NUHS), Singapore. ^[8] Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ^[9] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. ^[10] School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea. ^[11] Centre for Cardiovascular Biology and Disease Research, Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, La Trobe University, Bundoora, VIC, Australia. ^[12]

关键词 Chronic Cerebral Hypoperfusion DNA Methylation Intermittent Fasting Vascular Cognitive Impairment Vascular Dementia White Matter Lesion