换一批Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial.
第一作者：
Alasdair P S,Munro
第一单位：
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
作者：
Alasdair P S,Munro [1]
;
Shuo,Feng [2]
;
Leila,Janani [3]
;
Victoria,Cornelius [3]
;
Parvinder K,Aley [4]
;
Gavin,Babbage [5]
;
David,Baxter [6]
;
Marcin,Bula [7]
;
Katrina,Cathie [1]
;
Krishna,Chatterjee [8]
;
Kate,Dodd [7]
;
Yvanne,Enever [9]
;
Ehsaan,Qureshi [10]
;
Anna L,Goodman [11]
;
Christopher A,Green [10]
;
Linda,Harndahl [12]
;
John,Haughney [13]
;
Alexander,Hicks [14]
;
Agatha A,van der Klaauw [14]
;
Nasir,Kanji [2]
;
Vincenzo,Libri [15]
;
Martin J,Llewelyn [16]
;
Alastair C,McGregor [17]
;
Mina,Maallah [17]
;
Angela M,Minassian [18]
;
Patrick,Moore [19]
;
Mehmood,Mughal [6]
;
Yama F,Mujadidi [20]
;
Kyra,Holliday [21]
;
Orod,Osanlou [22]
;
Rostam,Osanlou [23]
;
Daniel R,Owens [1]
;
Mihaela,Pacurar [1]
;
Adrian,Palfreeman [24]
;
Daniel,Pan [24]
;
Tommy,Rampling [15]
;
Karen,Regan [25]
;
Stephen,Saich [5]
;
Tanveer,Bawa [26]
;
Dinesh,Saralaya [25]
;
Sunil,Sharma [16]
;
Ray,Sheridan [27]
;
Emma C,Thomson [28]
;
Shirley,Todd [27]
;
Chris,Twelves [21]
;
Robert C,Read [1]
;
Sue,Charlton [29]
;
Bassam,Hallis [29]
;
Mary,Ramsay [30]
;
Nick,Andrews [30]
;
Teresa,Lambe [2]
;
Jonathan S,Nguyen-Van-Tam [31]
;
Matthew D,Snape [4]
;
Xinxue,Liu [2]
;
Saul N,Faust [32]
;
COV-BOOST study group
作者单位：
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
[1]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
[2]
Imperial Clinical Trials Unit, Imperial College London, London, UK.
[3]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
[4]
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
[5]
Stockport NHS Foundation Trust, Stockport, UK.
[6]
NIHR Liverpool and Broadgreen Clinical Research Facility, Liverpool, UK.
[7]
NIHR Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
[8]
PHARMExcel, Welwyn Garden City, UK.
[9]
NIHR/Wellcome Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
[10]
Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK; MRC Clinical Trials Unit, University College London, London, UK.
[11]
Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
[12]
Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK.
[13]
Wellcome-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK.
[14]
NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK.
[15]
University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
[16]
Department of Infectious Diseases and Tropical Medicine, London Northwest University Healthcare, London, UK.
[17]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
[18]
The Adam Practice, Poole, UK.
[19]
NIHR Oxford Biomedical Research Centre, Oxford, UK.
[20]
NIHR Leeds Clinical Research Facility, Leeds Teaching Hospitals Trust and University of Leeds, Leeds, UK.
[21]
Public Health Wales, Betsi Cadwaladr University Health Board, Bangor University, Bangor, UK.
[22]
University of Liverpool, Liverpool, UK.
[23]
University Hospitals of Leicester NHS Trust, University of Leicester, Leicester, UK.
[24]
Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
[25]
Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK.
[26]
Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK.
[27]
Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
[28]
UK Health Security Agency, Porton Down, Porton, UK.
[29]
UK Health Security Agency, Colindale, London, UK.
[30]
Division of Epidemiology and Public Health, University of Nottingham School of Medicine, University of Nottingham, Nottingham, UK.
[31]
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK. Electronic address: s.faust@soton.ac.uk.
[32]
医学主题词
老年人(Aged);抗体, 病毒(Antibodies, Viral);女(雌)性(Female);人类(Humans);免疫球蛋白G(Immunoglobulin G);男(雄)性(Male);中年人(Middle Aged)
DOI
10.1016/S1473-3099(22)00271-7
PMID
35550261
发布时间
2025-05-30
- 浏览2
The Lancet. Infectious diseases
The Lancet. Infectious diseases
1131-1141页
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