Tolerability and treatment outcome of pembrolizumab in patients with advanced urothelial carcinoma and severe renal dysfunction.

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第一作者： Yuki,Kita

第一单位： Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

作者： Yuki,Kita ^[1] ; Katsuhiro,Ito ^[1] ; Sohei,Kanda ^[2] ; Akira,Joraku ^[3] ; Ritsuki,Yamaguchi ^[4] ; Yosuke,Shimizu ^[4] ; Naoki,Hayata ^[5] ; Shinya,Somiya ^[6] ; Noboru,Shibasaki ^[7] ; Takahiro,Kimura ^[8] ; Kensuke,Hikami ^[9] ; Takeshi,Yamada ^[10] ; Takashige,Abe ^[11] ; Kazunari,Tsuchihashi ^[12] ; Shuichi,Tatarano ^[13] ; Hiroyuki,Nishiyama ^[14] ; Hiroshi,Kitamura ^[15] ; Takashi,Kobayashi ^[16]

作者单位： Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan. ^[1] Department of Urology, Akita University, Akita, Japan. ^[2] Department of Urology, Ibaraki Prefectural Central Hospital, Kasama, Japan. ^[3] Department of Urology, Kobe City Nishi-Kobe Medical Center, Kobe, Japan. ^[4] Department of Urology, Kyoto Medical Center, Kyoto, Japan. ^[5] Department of Urology, Ijinkai Takeda General Hospital, Kyoto, Japan. ^[6] Department of Urology, Otsu City Hospital, Otsu, Japan. ^[7] Department of Urology, Jikei University School of Medicine, Tokyo, Japan. ^[8] Department of Urology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan. ^[9] Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan. ^[10] Department of Urology, Hokkaido University Graduate School of Medcine, Sapporo, Japan. ^[11] Department of Urology, Japanese Red Cross Otsu Hospital, Otsu, Japan. ^[12] Department of Urology, Kagoshima University, Kagoshima, Japan. ^[13] Department of Urology, University of Tsukuba, Tsukuba, Japan. ^[14] Department of Urology, University of Toyama, Toyama, Japan. ^[15] Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: selecao@kuhp.kyoto-u.ac.jp. ^[16]

关键词 Creatinine clearance Immune checkpoint inhibitor Pembrolizumab Renal dysfunction Urothelial carcinoma

主题词癌, 移行细胞(Carcinoma, Transitional Cell);人类(Humans);肾疾病(Kidney Diseases);治疗结果(Treatment Outcome);膀胱肿瘤(Urinary Bladder Neoplasms)

DOI 10.1016/j.urolonc.2022.04.005

PMID 35551861

发布时间 2022-09-22

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