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Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.

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第一作者： Kyung-Min,Lee

第一单位： Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.;Department of Life Sciences, College of Natural Science, Hanyang University, Seoul, Republic of South Korea.

作者： Kyung-Min,Lee ^[1] ; Chang-Ching,Lin ^[2] ; Alberto,Servetto ^[2] ; Joonbeom,Bae ^[3] ; Vishal,Kandagatla ^[2] ; Dan,Ye ^[2] ; GunMin,Kim ^[2] ; Dhivya R,Sudhan ^[2] ; Saurabh,Mendiratta ^[2] ; Paula I,González Ericsson ^[4] ; Justin M,Balko ^[5] ; Jeon,Lee ^[6] ; Spencer,Barnes ^[6] ; Venkat S,Malladi ^[6] ; Siamak,Tabrizi ^[2] ; Sangeetha M,Reddy ^[7] ; Seoyun,Yum ^[8] ; Ching-Wei,Chang ^[9] ; Katherine E,Hutchinson ^[10] ; Susan E,Yost ^[11] ; Yuan,Yuan ^[11] ; Zhijian J,Chen ^[8] ; Yang-Xin,Fu ^[3] ; Ariella B,Hanker ^[7] ; Carlos L,Arteaga ^[7]

作者单位： Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.;Department of Life Sciences, College of Natural Science, Hanyang University, Seoul, Republic of South Korea. ^[1] Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas. ^[2] Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. ^[3] Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee. ^[4] Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.;Departments of Medicine and Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee. ^[5] Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas. ^[6] Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.;Harold C. Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas. ^[7] Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas. ^[8] Oncology Biostatistics, Genentech, Inc., South San Francisco, California. ^[9] Oncology Biomarker Development, Genentech, Inc., South San Francisco, California. ^[10] Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, Duarte, California. ^[11]

医学主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);免疫逃避(Immune Evasion);膜蛋白质类(Membrane Proteins);小鼠(Mice);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc)

DOI 10.1158/2326-6066.CIR-21-0826

PMID 35561311

发布时间 2024-09-23

基金项目

P30 CA068485/CA/NCI NIH HHS/United States P30 CA142543/CA/NCI NIH HHS/United States P50 CA098131/CA/NCI NIH HHS/United States R01 CA224899/CA/NCI NIH HHS/United States

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Cancer immunology research

2022年10卷7期

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Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.

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Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.

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