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NO-dependent vasodilation and deep tumor penetration for cascade-amplified antitumor performance.

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第一作者： Qing,Xu

第一单位： Guangdong Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

作者： Qing,Xu ^[1] ; Gui,Chen ^[1] ; Guimei,Chen ^[1] ; Hualan,Wu ^[2] ; Yuanyuan,Yang ^[1] ; Ziyi,Mai ^[1] ; Rui,Sun ^[1] ; Ping,Luan ^[3] ; Chaowan,Guo ^[4] ; Meng,Yu ^[5] ; Zhenwei,Peng ^[6] ; Zhiqiang,Yu ^[7]

作者单位： Guangdong Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. ^[1] The First Clinical Medical School, Southern Medical University, Guangzhou 510515, China. ^[2] Guangdong Second Provincial General Hospital & Health Science Center, Shenzhen University, Shenzhen 518060, China. ^[3] Guangdong Marubi Biotechnology Co., Ltd. No 92 Banhe Road, Huangpu District, Guangzhou 510700, China. ^[4] Guangdong Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: yumeng999@smu.edu.cn. ^[5] Department of Radiation Oncology, Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: pzhenw@mail.sysu.edu.cn. ^[6] Guangdong Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: yuzq@smu.edu.cn. ^[7]

关键词 Deep tumor penetration Dilating blood vessels Nitric oxide Reactive nitrogen species Tumor-specific therapeutic

医学主题词谷胱甘肽(Glutathione);人类(Humans);一氧化氮(Nitric Oxide);活性氮(Reactive Nitrogen Species);活性氧(Reactive Oxygen Species);组织分布(Tissue Distribution);血管舒张(Vasodilation)

DOI 10.1016/j.jconrel.2022.05.022

PMID 35569586

发布时间 2022-08-01

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