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Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine.

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第一作者： Alexandra,Atalis

第一单位： Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.

作者： Alexandra,Atalis ^[1] ; Mark C,Keenum ^[1] ; Bhawana,Pandey ^[1] ; Alexander,Beach ^[2] ; Pallab,Pradhan ^[3] ; Casey,Vantucci ^[1] ; Laura,O'Farrell ^[4] ; Richard,Noel ^[4] ; Ritika,Jain ^[1] ; Justin,Hosten ^[1] ; Clinton,Smith ^[1] ; Liana,Kramer ^[1] ; Angela,Jimenez ^[1] ; Miguel Armenta,Ochoa ^[1] ; David,Frey ^[1] ; Krishnendu,Roy ^[5]

作者单位： Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. ^[1] School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA. ^[2] Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Marcus Center for Therapeutic Cell Characterization and Manufacturing, Georgia Institute of Technology, Atlanta, GA, USA; The Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA. ^[3] Physiological Research Laboratory, Georgia Institute of Technology, Atlanta, GA, USA. ^[4] Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Marcus Center for Therapeutic Cell Characterization and Manufacturing, Georgia Institute of Technology, Atlanta, GA, USA; The Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: krish.roy@gatech.edu. ^[5]

关键词 Adaptive immune response COVID-19 protein subunit vaccine Combination adjuvant Intranasal versus intramuscular vaccination Monophosphoryl lipid A SARS-CoV-2 spike protein