High-sensitivity quantification of antisense oligonucleotides for pharmacokinetic characterization.

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第一作者： Shilpi,Mahajan

第一单位： Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, South San Francisco, CA 94080, USA.

作者： Shilpi,Mahajan ^[1] ; Hui,Zhao ^[1] ; Kristina,Kovacina ^[1] ; Eric,Lachacz ^[1] ; Sany,Hoxha ^[1] ; Josolyn,Chan ^[1] ; Meina,Liang ^[1]

作者单位： Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, South San Francisco, CA 94080, USA. ^[1]

关键词 antisense oligonucleotides (ASOs)bioanalysis branched DNA (bDNA)dual-probe hybridization immunoassay (H-ECL)high-sensitivity quantification single-probe hybridization nuclease protection assay (H-ELISA)

主题词色谱法, 液相(Chromatography, Liquid);核酸杂交(Nucleic Acid Hybridization);寡核苷酸类, 反义(Oligonucleotides, Antisense)

DOI 10.4155/bio-2022-0035

PMID 35578971

发布时间 2022-05-20

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Bioanalysis

2022年14卷9期

603-613页

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High-sensitivity quantification of antisense oligonucleotides for pharmacokinetic characterization.

Bioanalysis

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High-sensitivity quantification of antisense oligonucleotides for pharmacokinetic characterization.

Bioanalysis

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Bioanalysis

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