Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis.

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作者： Roxana E,Oberkersch ^[1] ; Giovanna,Pontarin ^[1] ; Matteo,Astone ^[1] ; Marianna,Spizzotin ^[1] ; Liaisan,Arslanbaeva ^[1] ; Giovanni,Tosi ^[1] ; Emiliano,Panieri ^[2] ; Sara,Ricciardi ^[3] ; Maria Francesca,Allega ^[4] ; Alessia,Brossa ^[2] ; Paolo,Grumati ^[5] ; Benedetta,Bussolati ^[2] ; Stefano,Biffo ^[3] ; Saverio,Tardito ^[4] ; Massimo M,Santoro ^[6]

作者单位： Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy. ^[1] Molecular Biotechnology Center, University of Turin, Turin, Italy. ^[2] National Institute of Molecular Genetics (INGM) and Department of Biosciences, University of Milan, Milan, Italy. ^[3] Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G611BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G611QH, UK. ^[4] Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy. ^[5] Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy. Electronic address: massimo.santoro@unipd.it. ^[6]

关键词 angiogenesis aspartate metabolism endothelial metabolism mTOR signalling tumor angiogenesis