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A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome.

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第一作者： Jeffrey C,Hsiao

第一单位： Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

作者： Jeffrey C,Hsiao ^[1] ; Atara R,Neugroschl ^[2] ; Ashley J,Chui ^[3] ; Cornelius Y,Taabazuing ^[2] ; Andrew R,Griswold ^[4] ; Qinghui,Wang ^[2] ; Hsin-Che,Huang ^[3] ; Elizabeth L,Orth-He ^[3] ; Daniel P,Ball ^[2] ; Giorgos,Hiotis ^[3] ; Daniel A,Bachovchin ^[5]

作者单位： Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA. ^[1] Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. ^[2] Tri-Institutional PhD Program, Weill Cornell Medical College, Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, New York, USA. ^[3] Tri-Institutional MD-PhD Program, Weill Cornell Medical College, Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, New York, USA. ^[4] Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Tri-Institutional PhD Program, Weill Cornell Medical College, Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address: bachovcd@mskcc.org. ^[5]

关键词 CARD8 DPP8/9 inflammasomes proteasome protein disorder ubiquitin

医学主题词 CARD信号接头蛋白质类(CARD Signaling Adaptor Proteins);二肽基肽酶类和三肽基肽酶类(Dipeptidyl-Peptidases and Tripeptidyl-Peptidases);人类(Humans);炎性体(Inflammasomes);肿瘤蛋白质类(Neoplasm Proteins);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);泛素类(Ubiquitins)

DOI 10.1016/j.jbc.2022.102032

PMID 35580636

发布时间 2025-10-31

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