Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.

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作者： Sumin,Sun ^[1] ; Sheng,Huan ^[1] ; Zhanghao,Li ^[1] ; Yue,Yao ^[2] ; Ying,Su ^[1] ; Siwei,Xia ^[1] ; Shijun,Wang ^[3] ; Xuefen,Xu ^[1] ; Jiangjuan,Shao ^[1] ; Zili,Zhang ^[1] ; Feng,Zhang ^[1] ; Jinbo,Fu ^[4] ; Shizhong,Zheng ^[1]

作者单位： Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China. ^[1] School of Pharmacy, East China University of Science and Technology, Shanghai, China. ^[2] Shandong Co-innovation Center of TCM Formula, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. ^[3] Department of Pharmacy, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. ^[4]

关键词 Curcumol ER stress Liver fibrosis NICD Necroptosis Sirt1

主题词小鼠(Mice);动物(Animals);肝星状细胞(Hepatic Stellate Cells);抗衰老酶1(Sirtuin 1);小鼠, 近交ICR(Mice, Inbred ICR);肝硬化(Liver Cirrhosis)

DOI 10.7717/peerj.13376

PMID 35582617

发布时间 2023-01-12

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Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.

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Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.

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