Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane.

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作者： Siyoung,Kim ^[1] ; Jeeyun,Chung ^[2] ; Henning,Arlt ^[3] ; Alexander J,Pak ^[2] ; Robert V,Farese ^[3] ; Tobias C,Walther ^[4] ; Gregory A,Voth ^[5]

作者单位： Pritzker School of Molecular Engineering, University of Chicago, Chicago, United States. ^[1] Department of Molecular Metabolism, Harvard T H Chan School of Public Health, Boston, United States. ^[2] Department of Cell Biology, Harvard Medical School, Boston, United States. ^[3] Howard Hughes Medical Institute, Harvard T H Chan School of Public Health, Boston, United States. ^[4] Department of Chemical and Biological Engineering, Colorado School of Mines, Golden, United States. ^[5] Broad Institute of Harvard and MIT, Cambridge, United States. ^[6] Department of Chemistry, Chicago Center for Theoretical Chemistry, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, United States. ^[7]

关键词 human lipid droplets molecular biophysics molecular dynamics seipin structural biology

主题词内质网(Endoplasmic Reticulum);人类(Humans);膜(Membranes);磷脂类(Phospholipids);甘油三酯类(Triglycerides)

DOI 10.7554/eLife.75808

PMID 35583926

发布时间 2023-07-01

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