Synthesis and biological evaluation of thiazolidine-2-thione derivatives as novel xanthine oxidase inhibitors.

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第一作者： Mu-Xuan,Wang

第一单位： Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering and Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, Jiangsu, P.R. China.

作者： Mu-Xuan,Wang ^[1] ; Hong-Wei,Qin ^[2] ; Chao,Liu ^[3] ; Shen-Ming,Lv ^[1] ; Jia-Shu,Chen ^[3] ; Chun-Gu,Wang ^[1] ; Ying-Ying,Chen ^[3] ; Jia-Wei,Wang ^[1] ; Jin-Yue,Sun ^[3] ; Zhi-Xin,Liao ^[1]

作者单位： Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering and Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, Jiangsu, P.R. China. ^[1] School of Life Sciences and Bioengineering, Jining University, Qufu, Shandong, P.R. China. ^[2] Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, Jinan, Shandong, P.R. China. ^[3]

主题词酶抑制剂(Enzyme Inhibitors);人类(Humans);高尿酸血症(Hyperuricemia);构效关系(Structure-Activity Relationship);噻唑烷类(Thiazolidines);黄嘌呤氧化酶(Xanthine Oxidase)

DOI 10.1371/journal.pone.0268531

PMID 35584139

发布时间 2022-07-16

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