The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.

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第一作者： Leah,Schembs

第一单位： Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.

作者： Leah,Schembs ^[1] ; Ariane,Willems ^[2] ; Kerstin,Hasenpusch-Theil ^[3] ; James D,Cooper ^[4] ; Katie,Whiting ^[1] ; Karen,Burr ^[4] ; Sunniva M K,Bøstrand ^[1] ; Bhuvaneish T,Selvaraj ^[5] ; Siddharthan,Chandran ^[6] ; Thomas,Theil ^[7]

作者单位： Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK. ^[1] Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK. ^[2] Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK. ^[3] Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK. ^[4] Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK. ^[5] Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK. ^[6] Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK. Electronic address: thomas.theil@ed.ac.uk. ^[7]

关键词 CP: Neuroscience INPP5E dorsal and ventral patterning human cortex primary cilia sonic hedgehog telencephalon

主题词纤毛(Cilia);猬蛋白质类(Hedgehog Proteins);人类(Humans);类器官(Organoids);磷酸单酯水解酶类(Phosphoric Monoester Hydrolases);端脑(Telencephalon)

DOI 10.1016/j.celrep.2022.110811

PMID 35584663

发布时间 2024-02-14

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