Kinase-targeting small-molecule inhibitors and emerging bifunctional molecules.

导出原文传递

翻译打印收藏纠错

第一作者： Georg L,Goebel

第一单位： Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.

作者： Georg L,Goebel ^[1] ; Xiaqiu,Qiu ^[1] ; Peng,Wu ^[2]

作者单位： Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany. ^[1] Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen DK-2100, Denmark. Electronic address: peng.wu@mpi-dortmund.mpg.de. ^[2]

关键词 allosteric inhibitor covalent inhibitor kinase inhibitor proteolysis targeting chimera (PROTAC)proximity-inducing bifunctional molecule small molecule

主题词人类(Humans);蛋白激酶抑制剂(Protein Kinase Inhibitors);美国(United States);美国食品和药物管理局(United States Food and Drug Administration)

DOI 10.1016/j.tips.2022.04.006

PMID 35589447

发布时间 2022-10-26

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交