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The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.

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作者单位: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [1] The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [2] Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, NY, United States. [3] Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States. [4] Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, United States. [5] Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, United States. [6] Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States. [7] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. [8] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States. [9] Department of Epidemiology, University of Washington, Seattle, WA, United States. [10] Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States. [11] Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. [12] Division of Rheumatology, Department of Medicine, National Jewish Health, Denver, CO, United States. [13] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States. [14] Department of Medicine, Harvard Medical School, Boston, MA, United States. [15] Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States. [16] National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, United States. [17] Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, United States. [18] Whitaker Cardiovascular Institute and Cardiology Section, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, United States. [19] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. [20] College of Public Health, University of Kentucky, Lexington, KY, United States. [21] Department of Population Health Services, Geisinger Health, Danville, PA, United States. [22] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. [23] Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States. [24] Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States. [25] Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States. [26] The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States. [27] Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anchutz Medical Camus, Aurora, CA, United States. [28] Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States. [29] Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, United States. [30] Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States. [31] Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, United States. [32] Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States. [33] Division of Cardiology, University of Illinois at Chicago, Chicago, IL, United States. [34] Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. [35] Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, United States. [36] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States. [37] Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, United States. [38] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. [39] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [40]
DOI 10.3389/fendo.2022.863893
PMID 35592775
发布时间 2023-08-02
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