首页> Molecular oncology> Altered splicing of ATG16-L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non-small cell lung cancer.

Altered splicing of ATG16-L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non-small cell lung cancer.

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第一作者： Anne-Sophie,Hatat

第一单位： Team "RNA Splicing, Cell Signaling and Response to Therapies", Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Grenoble Alpes University, France.

作者： Anne-Sophie,Hatat ^[1] ; Clara,Benoit-Pilven ^[2] ; Amélie,Pucciarelli ^[1] ; Florence,de Fraipont ^[3] ; Lucie,Lamothe ^[1] ; Pascal,Perron ^[1] ; Amandine,Rey ^[2] ; Matteo Giaj,Levra ^[4] ; Anne-Claire,Toffart ^[4] ; Didier,Auboeuf ^[2] ; Beatrice,Eymin ^[1] ; Sylvie,Gazzeri ^[1]

作者单位： Team "RNA Splicing, Cell Signaling and Response to Therapies", Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Grenoble Alpes University, France. ^[1] Laboratory of Biology and Modelling of the Cell, Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Lyon, France. ^[2] Team "RNA Splicing, Cell Signaling and Response to Therapies", Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Grenoble Alpes University, France.;Molecular Genetic Unit, Grenoble-Alpes University Hospital, France. ^[3] Team "RNA Splicing, Cell Signaling and Response to Therapies", Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Grenoble Alpes University, France.;Thoracic Oncology Unit, Grenoble-Alpes University Hospital, France. ^[4]

关键词 ATG16-L1 EGFR-TKI autophagy non-small cell lung cancer resistance