Rapid degradation of protein tyrosine phosphatase 1B in sickle cells: Possible contribution to sickle cell membrane weakening.

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第一作者： Panae,Noomuna

第一单位： Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.

作者： Panae,Noomuna ^[1] ; John M,Hausman ^[2] ; Ruhani,Sansoya ^[1] ; Theodosia,Kalfa ^[2] ; Mary,Risinger ^[1] ; Philip S,Low ^[3]

作者单位： Department of Chemistry, Purdue University, West Lafayette, Indiana, USA. ^[1] Institute for Drug Discovery, Purdue University, West Lafayette, Indiana, USA. ^[2] Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. ^[3] Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. ^[4]

关键词 Band 3 tyrosine phosphorylation PTP1B calpain proteolysis cleavage of PTP1B phosphatase activity sickle cells

主题词贫血, 镰状细胞性(Anemia, Sickle Cell);红细胞膜(Erythrocyte Membrane);人类(Humans);膜蛋白质类(Membrane Proteins);磷酰化(Phosphorylation);蛋白质酪氨酸磷酸酶, 非受体1型(Protein Tyrosine Phosphatase, Non-Receptor Type 1);酪氨酸(Tyrosine)

DOI 10.1096/fj.202100809RR

PMID 35593742

发布时间 2023-06-02

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