Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development.

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作者： Aditya H,Gaur ^[1] ; John C,Panetta ^[2] ; Amber M,Smith ^[3] ; Ronald H,Dallas ^[2] ; Burgess B,Freeman ^[2] ; Tracy B,Stewart ^[2] ; Li,Tang ^[2] ; Elizabeth,John ^[4] ; Kristen C,Branum ^[2] ; Nehali D,Patel ^[2] ; Shelley,Ost ^[3] ; Ryan N,Heine ^[2] ; Julie L,Richardson ^[2] ; Jared T,Hammill ^[5] ; Lidiya,Bebrevska ^[6] ; Fabian,Gusovsky ^[7] ; Noritsugu,Maki ^[7] ; Toshiharu,Yanagi ^[7] ; Patricia M,Flynn ^[2] ; James S,McCarthy ^[8] ; Stephan,Chalon ^[6] ; R Kiplin,Guy ^[5]

作者单位： Translational Trials Unit, MS 600, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States. Electronic address: aditya.gaur@stjude.org. ^[1] Translational Trials Unit, MS 600, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States. ^[2] University of Tennessee Health Science Center, Memphis, TN, United States. ^[3] EJOHN Consulting, Richland, WA, United States. ^[4] University of Kentucky College of Pharmacy, Lexington, KY, United States. ^[5] Medicines for Malaria Venture, Geneva, Switzerland. ^[6] Eisai Inc., Cambridge, MA, United States. ^[7] Department of Clinical Tropical Medicine, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. ^[8]

关键词 Antimalarial Pharmacoboost Pharmacodynamics Pharmacokinetics SJ733

主题词抗疟药(Antimalarials);叶酸拮抗剂(Folic Acid Antagonists);人类(Humans);异喹啉类(Isoquinolines);疟疾(Malaria);疟疾, 恶性(Malaria, Falciparum);恶性疟原虫(Plasmodium falciparum)

DOI 10.1016/j.ebiom.2022.104065

PMID 35598441

发布时间 2024-09-23

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Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development.

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Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development.

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