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Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis.

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第一作者： Christine,Young

第一单位： MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.;Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom.

作者： Christine,Young ^[1] ; John R,Russell ^[2] ; Louie N,Van De Lagemaat ^[3] ; Hannah,Lawson ^[3] ; Christopher,Mapperley ^[3] ; Kamil R,Kranc ^[3] ; Maria A,Christophorou ^[4]

作者单位： MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.;Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom. ^[1] MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. ^[2] Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom.;Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M6BQ, United Kingdom. ^[3] MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.;Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom.;Epiegetics, Babraham Institute, Cambridge CB22 3AT, United Kingdom. ^[4]

关键词 Ageing Bone marrow Differentiation Haematopoietic development Peptidylarginine deiminase IV (PADI4)Regeneration

医学主题词动物(Animals);细胞分化(Cell Differentiation);水解酶类(Hydrolases);哺乳动物(Mammals)

DOI 10.1242/bio.059143

PMID 35603697

发布时间 2025-05-30

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