Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma.

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第一作者： Hui,Xing

第一单位： Division of Anti-tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.;School of Pharmaceutical Sciences, University of Chinese Academy of Sciences, Beijing, China.

作者： Hui,Xing ^[1] ; Mengshi,Gao ^[1] ; Yuxiang,Wang ^[2] ; Xu,Zhang ^[1] ; Jiajie,Shi ^[2] ; Xiang,Wang ^[2] ; Xueling,Liu ^[2] ; Qingyang,Ma ^[3] ; Xiangyin,Kong ^[3] ; Chunhao,Yang ^[4] ; Jian,Ding ^[5] ; Linghua,Meng ^[1]

作者单位： Division of Anti-tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.;School of Pharmaceutical Sciences, University of Chinese Academy of Sciences, Beijing, China. ^[1] Division of Anti-tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ^[2] Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China. ^[3] Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ^[4] School of Pharmaceutical Sciences, University of Chinese Academy of Sciences, Beijing, China.;Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ^[5]

关键词 CDKN1A CRISPR-SAM CYH33 ESCC EZH2 PI3Kα inhibitor cell cycle resistance

主题词细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);食管肿瘤(Esophageal Neoplasms);人类(Humans)

DOI 10.1002/ctm2.835

PMID 35604910

发布时间 2024-08-30

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Clinical and translational medicine

2022年12卷5期

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Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma.

Clinical and translational medicine

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Clinical and translational medicine

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Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma.

Clinical and translational medicine

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Clinical and translational medicine

相关期刊

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