Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3.

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作者： Tiantian,Luo ^[1] ; Zhigang,Guo ^[2] ; Dan,Liu ^[3] ; Zhongzhou,Guo ^[4] ; Qiao,Wu ^[3] ; Qinxian,Li ^[5] ; Rongzhan,Lin ^[4] ; Peier,Chen ^[3] ; Caiwen,Ou ^[3] ; Minsheng,Chen ^[1]

作者单位： Department of Cardiology, Laboratory of Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ^[1] Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China. ^[2] Department of Cardiology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Lab of Shock and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China. ^[3] Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. ^[4] Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ^[5] Guangdong Provincial Key Laboratory of Shock and Microcirculation, Dongguan Hospital of Southern Medical University, Southern Medical University, Guangzhou, China. ^[6]

关键词 Proline/serine-rich coiled-coil protein 1 atherosclerosis flavin monooxygenase 3 gut microbiota trimethylamine N-oxide

主题词动物(Animals);动脉粥样硬化(Atherosclerosis);细菌(Bacteria);甲胺类(Methylamines);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);混合功能氧化酶类(Mixed Function Oxygenases);氧合酶类(Oxygenases);磷蛋白类(Phosphoproteins);斑块, 动脉粥样硬化(Plaque, Atherosclerotic)

DOI 10.1080/19490976.2022.2077602

PMID 35613310

发布时间 2022-12-21

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Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3.

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Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3.

Gut microbes

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Gut microbes

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