Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony.

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作者： Scott,Rich ^[1] ; Homeira,Moradi Chameh ^[1] ; Jeremie,Lefebvre ^[2] ; Taufik A,Valiante ^[3]

作者单位： Division of Clinical and Computational Neuroscience, Krembil Brain Institute, Toronto, ON M5T 1M8, Canada; Center for Advancing Neurotechnological Innovation to Application (CRANIA), University of Toronto, Toronto, ON M5S 1A1, Canada. ^[1] Division of Clinical and Computational Neuroscience, Krembil Brain Institute, Toronto, ON M5T 1M8, Canada; Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada; Department of Mathematics, University of Toronto, Toronto, ON M5S 1A1, Canada; Center for Advancing Neurotechnological Innovation to Application (CRANIA), University of Toronto, Toronto, ON M5S 1A1, Canada. Electronic address: jeremie.lefebvre@uottawa.ca. ^[2] Division of Clinical and Computational Neuroscience, Krembil Brain Institute, Toronto, ON M5T 1M8, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 1A1, Canada; Electrical and Computer Engineering, University of Toronto, Toronto, ON M5S 1A1, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A1, Canada; Max Planck-University of Toronto Centre for Neural Science and Technology, University of Toronto, Toronto, ON M5S 1A1, Canada; Center for Advancing Neurotechnological Innovation to Application (CRANIA), University of Toronto, Toronto, ON M5S 1A1, Canada. Electronic address: taufik.valiante@uhn.ca. ^[3]

关键词 CP: Neuroscience computational neuroscience epilepsy human neuronal electrophysiology neuronal heterogeneity seizure

主题词癫痫(Epilepsy);人类(Humans);神经元(Neurons);锥体细胞(Pyramidal Cells);发作(Seizures)

DOI 10.1016/j.celrep.2022.110863

PMID 35613586

发布时间 2022-10-19

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