Quantitation of the A<sub>2A</sub> Adenosine Receptor Density in the Striatum of Mice and Pigs with [<sup>18</sup>F]FLUDA by Positron Emission Tomography.

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作者： Daniel,Gündel ^[1] ; Magali,Toussaint ^[1] ; Thu Hang,Lai ^[1] ; Winnie,Deuther-Conrad ^[2] ; Paul,Cumming ^[1] ; Susann,Schröder ^[3] ; Rodrigo,Teodoro ^[4] ; Rareş-Petru,Moldovan ^[2] ; Francisco,Pan-Montojo ^[1] ; Bernhard,Sattler ^[5] ; Klaus,Kopka ^[1] ; Osama,Sabri ^[6] ; Peter,Brust ^[7]

作者单位： Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 04308 Leipzig, Germany. ^[1] Department of Research and Development, ROTOP Pharmaka Ltd., 01328 Dresden, Germany. ^[2] Department of Nuclear Medicine, Bern University Hospital, 3010 Bern, Switzerland. ^[3] School of Psychology and Counselling, Queensland University of Technology, Brisbane 4000, Australia. ^[4] Department of Research and Development, Life Molecular Imaging GmbH, 13353 Berlin, Germany. ^[5] Department of Psychiatry, University Hospital Munich, Ludwig-Maximilians-Universität (LMU) Munich, 80336 Munich, Germany. ^[6] Department of Neurology, University Hospital Munich, Ludwig-Maximilians-Universität (LMU) Munich, 81377 Munich, Germany. ^[7] Department for Nuclear Medicine, University Hospital Leipzig, 04103 Leipzig, Germany. ^[8] Faculty of Chemistry and Food Chemistry, School of Science, TU Dresden, 01069 Dresden, Germany. ^[9] The Lübeck Institute of Experimental Dermatology, University Medical Center Schleswig-Holstein, 23562 Lübeck, Germany. ^[10]

关键词 7–(3–(4–(2–[18F]fluoroethoxy–1,1,2,2–d4)phenyl)propyl)–2–(furan–2–yl)–7H–pyrazolo[4,3–e][1,2,4]triazolo–[1,5–c]pyrimidin–5–amine ([18F]FLUDA)A2A adenosine receptor (A2AAR)Huntington’s disease (HD)Parkinson’s disease (PD)kinetic analysis preclinical positron emission tomography (PET)simplified reference tissue model (SRTM)

DOI 10.3390/ph15050516

PMID 35631343

发布时间 2022-07-16

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