TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.

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作者： Wei,Liu ^[1] ; Yuechao,Zhao ^[2] ; Guangfu,Wang ^[3] ; Shuang,Feng ^[4] ; Xuhui,Ge ^[5] ; Wu,Ye ^[5] ; Zhuanghui,Wang ^[5] ; Yufeng,Zhu ^[5] ; Weihua,Cai ^[6] ; Jianling,Bai ^[7] ; Xuhui,Zhou ^[8]

作者单位： Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China. ^[1] Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China; Department of Orthopedics, PLA Navy No.905 Hospital, Secondary Military Medical University, Shanghai, China. ^[2] Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Pancreas Institute, Nanjing Medical University, Nanjing, Jiangsu, China. ^[3] Department of Encephalopathy, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. ^[4] Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. ^[5] Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: caiwhspine@sina.com. ^[6] Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: baijianling@njmu.edu.cn. ^[7] Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: zhouxuhui@smmu.edu.cn. ^[8]

关键词 Autophagic cell death Osteosarcoma ROS TRIM22/NRF2 Warburg effect

主题词 AMP活化蛋白激酶类(AMP-Activated Protein Kinases);青少年(Adolescent);自噬(Autophagy);骨肿瘤(Bone Neoplasms);人类(Humans);次要组织相容性抗原(Minor Histocompatibility Antigens);NF-E2相关因子2(NF-E2-Related Factor 2);骨肉瘤(Osteosarcoma);活性氧(Reactive Oxygen Species);阻遏蛋白质类(Repressor Proteins);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)

DOI 10.1016/j.redox.2022.102344

PMID 35636015

发布时间 2022-07-16

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Redox biology

2022年53卷

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TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.

Redox biology

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Redox biology

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TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.

Redox biology

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Redox biology

相关期刊

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