The pathogenesis of, and pharmacological treatment for, Canavan disease.

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第一作者： Huijun,Wei

第一单位： Johns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA.

作者： Huijun,Wei ^[1] ; John R,Moffett ^[2] ; Man,Amanat ^[3] ; Ali,Fatemi ^[4] ; Takashi,Tsukamoto ^[5] ; Aryan M,Namboodiri ^[6] ; Barbara S,Slusher ^[7]

作者单位： Johns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA. ^[1] Department of Anatomy, Physiology and Genetics and Neuroscience Program, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA. Electronic address: john.moffett@usuhs.edu. ^[2] Kennedy Krieger Institute, Baltimore, MD 21205, USA. ^[3] Department of Neurology, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Behavioral Science, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Kennedy Krieger Institute, Baltimore, MD 21205, USA. ^[4] Johns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA. ^[5] Department of Anatomy, Physiology and Genetics and Neuroscience Program, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA. ^[6] Johns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Psychiatry, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: bslusher@jhmi.edu. ^[7]

关键词 Aspartate N-acetyltransferase (Asp-NAT)Aspartoacylase (ASPA)Canavan disease (CD)N-acetylaspartate (NAA)NaDC3

主题词酰胺基水解酶类(Amidohydrolases);动物(Animals);脑(Brain);卡纳万病(Canavan Disease);疾病模型, 动物(Disease Models, Animal);少突神经胶质(Oligodendroglia)

DOI 10.1016/j.drudis.2022.05.019

PMID 35636725

发布时间 2025-02-26

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