Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB<sub>1</sub> receptors.

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作者： Yoshinori,Takemura ^[1] ; Yuka,Sudo ^[2] ; Tomoya,Saeki ^[3] ; Shinji,Kurata ^[4] ; Tsutomu,Suzuki ^[3] ; Tomohisa,Mori ^[5] ; Yasuhito,Uezono ^[6]

作者单位： Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan; Department of Anesthesiology, Toyama University Hospital, Toyama-shi, Toyama, Japan. ^[1] Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. ^[2] Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan. ^[3] Department of Anesthesiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Nagasaki, Japan. ^[4] Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan. Electronic address: t-mori@hoshi.ac.jp. ^[5] Division of Cancer Pathophysiology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Pain Control Research, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan. Electronic address: yuezono@jikei.ac.jp. ^[6]

关键词 Antinociceptive effect Cannabinoid G protein-coupled inwardly-rectifying potassium channels Spinal cord μ-Opioid

主题词动物(Animals);G蛋白偶联内向整流钾通道(G Protein-Coupled Inwardly-Rectifying Potassium Channels);小鼠(Mice);吗啡(Morphine);神经痛(Neuralgia);受体, 大麻酚(Receptors, Cannabinoid);受体, 阿片样, μ(Receptors, Opioid, mu)

DOI 10.1016/j.jphs.2022.04.002

PMID 35641032

发布时间 2022-06-03

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