首页> Cell biology and toxicology> Direct transcriptomic comparison of xenobiotic metabolism and toxicity pathway induction of airway epithelium models at an air-liquid interface generated from induced pluripotent stem cells and primary bronchial epithelial cells.

Direct transcriptomic comparison of xenobiotic metabolism and toxicity pathway induction of airway epithelium models at an air-liquid interface generated from induced pluripotent stem cells and primary bronchial epithelial cells.

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第一作者： Ivo,Djidrovski

第一单位： The Biosphere, Newcells Biotech Ltd., Draymans way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK.;Biosciences Institute, The International Centre for Life, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK.

作者： Ivo,Djidrovski ^[1] ; Maria,Georgiou ^[2] ; Elena,Tasinato ^[3] ; Martin O,Leonard ^[4] ; Jelle,Van den Bor ^[5] ; Majlinda,Lako ^[2] ; Lyle,Armstrong ^[6]

作者单位： The Biosphere, Newcells Biotech Ltd., Draymans way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK.;Biosciences Institute, The International Centre for Life, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK. ^[1] Biosciences Institute, The International Centre for Life, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK. ^[2] The Biosphere, Newcells Biotech Ltd., Draymans way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK. ^[3] Toxicology Department, Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Campus, Chilton, OX11 0RQ, UK. ^[4] Department of Medicinal Chemistry, Faculty of Science, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. ^[5] The Biosphere, Newcells Biotech Ltd., Draymans way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK. lyle.armstrong@ncl.ac.uk.;Biosciences Institute, The International Centre for Life, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK. lyle.armstrong@ncl.ac.uk. ^[6]

关键词 Airway epithelium Air–liquid interface Induced pluripotent stem cells Toxicity assessment Transcriptomics

医学主题词人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);异生物质(Xenobiotics);呼吸道黏膜(Respiratory Mucosa);上皮(Epithelium);上皮细胞(Epithelial Cells)

DOI 10.1007/s10565-022-09726-0

PMID 35641671

发布时间 2025-05-30

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