换一批
换一批MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy <i>via</i> targeting ATG4B.
作者：
关键词
3-MA, 3-methyladenine3′ UTR, 3′ untranslated regionANF, atrial natriuretic factorATG4BATG4B, autophagy related gene 4BAutophagic fluxAutophagyBNP, brain natriuretic polypeptideBaf A1, bafilomycin A1CQ, ChloroquineEF, ejection fractionFS, fractional shorteningGFP, green fluorescent proteinHE, hematoxylin–eosinISO, isoprenalineIVS,d: interventricular septal wall dimension at end-diastole, IVS,s: interventricular septal well dimension at end-systoleIsoprenalineLC3LC3, microtubule-associated protein 1 light chain 3LV Vol,d, left ventricular end-diastolic volumeLV Vol,s, left ventricular end-systolic volumeLVID,d, left ventricular end-diastolic internal diameterLVID,s, left ventricular end-systolic internal diameterLVPW,d, left ventricular end-diastolic posterior wall thicknessLVPW,s, left ventricular end-systolic posterior wall thicknessMiceNS, normal salineNeonatal rat cardiomyocytesPSR, Picric–Sirius redPathological cardiac hypertrophymTOR, mammalian target of rapamycinmiR-34c-5pmiRNA, microRNAqRT-PCR, quantitative real-time polymerase chain reactionβ-AR, β-adrenergic receptorβ-MHC, beta-myosin heavy chain
DOI
10.1016/j.apsb.2021.09.020
PMID
35646533
发布时间
2022-07-16
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Acta pharmaceutica Sinica. B
2022年12卷5期
2374-2390页
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