Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis.

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作者： Peipei,Ding ^[1] ; Yanqing,Xu ^[1] ; Luying,Li ^[1] ; Xinyue,Lv ^[1] ; Ling,Li ^[1] ; Jianfeng,Chen ^[1] ; Danlei,Zhou ^[1] ; Xiaochao,Wang ^[1] ; Qi,Wang ^[1] ; Wei,Zhang ^[1] ; Tian,Liao ^[2] ; Qing-Hai,Ji ^[2] ; Qun-Ying,Lei ^[3] ; Weiguo,Hu ^[4]

作者单位： Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China. ^[1] Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. ^[2] Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China. ^[3] Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China. Electronic address: weiguohu@fudan.edu.cn. ^[4]

关键词 C5a C5aR1 CP: cancer cathepsin D colorectal cancer β-catenin

主题词结直肠肿瘤(Colorectal Neoplasms);补体激活(Complement Activation);补体C5a(Complement C5a);人类(Humans);钾通道(Potassium Channels);β连环素(beta Catenin)

DOI 10.1016/j.celrep.2022.110851

PMID 35649359

发布时间 2022-09-06

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