Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity.

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第一作者： Yuanyuan,Zhao

第一单位： School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.

作者： Yuanyuan,Zhao ^[1] ; Bing,Zhang ^[2] ; Yiming,Ma ^[3] ; Fuqiang,Zhao ^[4] ; Jianan,Chen ^[4] ; Bingzhi,Wang ^[5] ; Hua,Jin ^[1] ; Fulai,Zhou ^[1] ; Jiawei,Guan ^[1] ; Qian,Zhao ^[1] ; Hongying,Wang ^[3] ; Qian,Liu ^[4] ; Fangqing,Zhao ^[2] ; Xia,Wang ^[6]

作者单位： School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. ^[1] Beijing Institutes of Life Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing, 100101, China. ^[2] State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. ^[3] Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. ^[4] Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. ^[5] Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. ^[6] Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China. ^[7]

关键词 colorectal cancer organoids preclinical model tumor heterogeneity

主题词结直肠肿瘤(Colorectal Neoplasms);氟尿嘧啶(Fluorouracil);人类(Humans);类器官(Organoids)

DOI 10.1002/advs.202201539

PMID 35652270

发布时间 2022-08-09

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2022年9卷22期

e2201539页

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Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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