The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8<sup>+</sup> cytotoxic T-cell response.

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作者： Samrat T,Kundu ^[1] ; B Leticia,Rodriguez ^[1] ; Laura A,Gibson ^[1] ; Amanda N,Warner ^[1] ; Mabel G,Perez ^[1] ; Rakhee,Bajaj ^[1] ; Jared J,Fradette ^[1] ; Caleb A,Class ^[2] ; Luisa M,Solis ^[3] ; Frank R,Rojas Alvarez ^[3] ; Ignacio I,Wistuba ^[3] ; Lixia,Diao ^[4] ; Fengju,Chen ^[5] ; Mohit,Sachdeva ^[6] ; Jing,Wang ^[4] ; David G,Kirsch ^[6] ; Chad J,Creighton ^[7] ; Don L,Gibbons ^[4]

作者单位： Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ^[1] Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ^[2] Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ^[3] Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ^[4] Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA. ^[5] Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA. ^[6] Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA. ^[7] Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA. ^[8] Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ^[9]

关键词 CD8+ T lymphocytes CTL EMT Foxf2 Zeb1 antitumor immune response interleukin-2 lung cancer microRNA-183/96/182 tumor immune microenvironment