HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function.

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第一作者： Yosuke,Mitani

第一单位： Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

作者： Yosuke,Mitani ^[1] ; Shinya,Ohashi ^[1] ; Osamu,Kikuchi ^[1] ; Yukie,Nakai ^[1] ; Tomomi,Ida ^[1] ; Ayaka,Mizumoto ^[1] ; Yoshihiro,Yamamoto ^[1] ; Tomoki,Saito ^[1] ; Shigeki,Kataoka ^[1] ; Junichi,Matsubara ^[1] ; Atsushi,Yamada ^[1] ; Masashi,Kanai ^[1] ; Shigemi,Matsumoto ^[1] ; Hiroaki,Sakai ^[2] ; Kiyotsugu,Yoshikawa ^[3] ; Eijiro,Nakamura ^[4] ; Manabu,Muto ^[5]

作者单位： Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. ^[1] DSK Project, Medical Innovation Center, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. ^[2] Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Keisui-kan, 97-1 Minami-hodate Kodo, Kyotanabe, Kyoto, W604610-0395, Japan. ^[3] Department of Urology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. ^[4] Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. mmuto@kuhp.kyoto-u.ac.jp. ^[5]

主题词结直肠肿瘤(Colorectal Neoplasms);人类(Humans);突变(Mutation);癌基因(Oncogenes);磷酰化(Phosphorylation);精神运动性激动(Psychomotor Agitation)

DOI 10.1038/s41598-022-13189-y

PMID 35654814

发布时间 2022-07-28

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