首页> Journal of molecular neuroscience : MN> Combined in Silico Prediction Methods, Molecular Dynamic Simulation, and Molecular Docking of FOXG1 Missense Mutations: Effect on FoxG1 Structure and Its Interactions with DNA and Bmi-1 Protein.

Combined in Silico Prediction Methods, Molecular Dynamic Simulation, and Molecular Docking of FOXG1 Missense Mutations: Effect on FoxG1 Structure and Its Interactions with DNA and Bmi-1 Protein.

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第一作者： Marwa,Kharrat

第一单位： Laboratory of Molecular and Functional Genetics, Faculty of Science, Sfax University, Sfax, Tunisia. marwa.kharrat.feki@gmail.com.

作者： Marwa,Kharrat ^[1] ; Chahnez Charfi,Triki ^[2] ; Olfa,Alila-Fersi ^[3] ; Olfa,Jallouli ^[2] ; Bassem,Khemakham ^[4] ; Salma,Mallouli ^[2] ; Marwa,Maalej ^[3] ; Marwa,Ammar ^[3] ; Fakher,Frikha ^[5] ; Fatma,Kamoun ^[2] ; Faiza,Fakhfakh ^[6]

作者单位： Laboratory of Molecular and Functional Genetics, Faculty of Science, Sfax University, Sfax, Tunisia. marwa.kharrat.feki@gmail.com. ^[1] Child Neurology Department, Hedi Chaker Hospital, Sfax, Tunisia.;Research Laboratory (LR19ES15), Sfax Medical School, Sfax University, Sfax, Tunisia. ^[2] Laboratory of Molecular and Functional Genetics, Faculty of Science, Sfax University, Sfax, Tunisia. ^[3] Laboratory of Plant Biotechnology, Faculty of Sciences of Sfax, Sfax University, Sfax, Tunisia. ^[4] Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia. ^[5] Laboratory of Molecular and Functional Genetics, Faculty of Science, Sfax University, Sfax, Tunisia. faiza.fakhfakh02@gmail.com. ^[6]

关键词 Congenital Rett syndrome FoxG1 Missense mutations Molecular docking Molecular dynamic simulation

医学主题词 DNA(DNA);叉头转录因子类(Forkhead Transcription Factors);分子动力学模拟(Molecular Dynamics Simulation);突变(Mutation);突变, 误义(Mutation, Missense);神经组织蛋白质类(Nerve Tissue Proteins)

DOI 10.1007/s12031-022-02032-8

PMID 35654936

发布时间 2022-08-16

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准确一般字义偏差语意偏离译文作用小提交