换一批
换一批A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.
第一作者：
Marijana,Vujkovic
第一单位：
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
作者：
Marijana,Vujkovic [1]
;
Shweta,Ramdas [2]
;
Kim M,Lorenz [3]
;
Xiuqing,Guo [4]
;
Rebecca,Darlay [5]
;
Heather J,Cordell [5]
;
Jing,He [6]
;
Yevgeniy,Gindin [7]
;
Chuhan,Chung [7]
;
Robert P,Myers [8]
;
Carolin V,Schneider [2]
;
Joseph,Park [9]
;
Kyung Min,Lee [10]
;
Marina,Serper [1]
;
Rotonya M,Carr [11]
;
David E,Kaplan [1]
;
Mary E,Haas [12]
;
Matthew T,MacLean [2]
;
Walter R,Witschey [13]
;
Xiang,Zhu [14]
;
Catherine,Tcheandjieu [15]
;
Rachel L,Kember [16]
;
Henry R,Kranzler [16]
;
Anurag,Verma [17]
;
Ayush,Giri [18]
;
Derek M,Klarin [19]
;
Yan V,Sun [20]
;
Jie,Huang [21]
;
Jennifer E,Huffman [22]
;
Kate Townsend,Creasy [2]
;
Nicholas J,Hand [2]
;
Ching-Ti,Liu [23]
;
Michelle T,Long [24]
;
Jie,Yao [4]
;
Matthew,Budoff [25]
;
Jingyi,Tan [4]
;
Xiaohui,Li [4]
;
Henry J,Lin [4]
;
Yii-Der Ida,Chen [4]
;
Kent D,Taylor [4]
;
Ruey-Kang,Chang [4]
;
Ronald M,Krauss [26]
;
Silvia,Vilarinho [27]
;
Joseph,Brancale [27]
;
Jonas B,Nielsen [28]
;
Adam E,Locke [28]
;
Marcus B,Jones [28]
;
Niek,Verweij [28]
;
Aris,Baras [28]
;
K Rajender,Reddy [29]
;
Brent A,Neuschwander-Tetri [30]
;
Jeffrey B,Schwimmer [31]
;
Arun J,Sanyal [32]
;
Naga,Chalasani [33]
;
Kathleen A,Ryan [34]
;
Braxton D,Mitchell [34]
;
Dipender,Gill [35]
;
Andrew D,Wells [36]
;
Elisabetta,Manduchi [2]
;
Yedidya,Saiman [37]
;
Nadim,Mahmud [38]
;
Donald R,Miller [39]
;
Peter D,Reaven [40]
;
Lawrence S,Phillips [41]
;
Sumitra,Muralidhar [42]
;
Scott L,DuVall [43]
;
Jennifer S,Lee [15]
;
Themistocles L,Assimes [44]
;
Saiju,Pyarajan [45]
;
Kelly,Cho [45]
;
Todd L,Edwards [46]
;
Scott M,Damrauer [47]
;
Peter W,Wilson [48]
;
J Michael,Gaziano [49]
;
Christopher J,O'Donnell [45]
;
Amit V,Khera [50]
;
Struan F A,Grant [51]
;
Christopher D,Brown [2]
;
Philip S,Tsao [44]
;
Danish,Saleheen [52]
;
Luca A,Lotta [28]
;
Lisa,Bastarache [6]
;
Quentin M,Anstee [53]
;
Ann K,Daly [54]
;
James B,Meigs [55]
;
Jerome I,Rotter [4]
;
Julie A,Lynch [56]
;
Regeneron Genetics Center [9]
;
Geisinger-Regeneron DiscovEHR Collaboration [57]
;
EPoS Consortium [58]
;
VA Million Veteran Program ;
Daniel J,Rader ;
Benjamin F,Voight ;
Kyong-Mi,Chang
作者单位：
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[1]
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[2]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[3]
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
[4]
Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
[5]
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
[6]
Gilead Sciences, Inc., Foster City, CA, USA.
[7]
Gilead Sciences, Inc., Foster City, CA, USA.;The Liver Company, Palo Alto, CA, USA.
[8]
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[9]
VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
[10]
Division of Gastroenterology, University of Washington, Seattle, WA, USA.
[11]
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[12]
Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[13]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Statistics, The Pennsylvania State University, University Park, PA, USA.;Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.;Department of Statistics, Stanford University, Stanford, CA, USA.
[14]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
[15]
Mental Illness Research Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[16]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[17]
Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
[18]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Division of Vascular Surgery, Stanford University School of Medicine, Palo Alto, CA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[19]
Atlanta VA Medical Center, Decatur, GA, USA.;Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
[20]
School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong, China.
[21]
VA Boston Healthcare System, Boston, MA, USA.
[22]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[23]
Department of Medicine, Section of Gastroenterology, Boston University School of Medicine, Boston, MA, USA.
[24]
Department of Cardiology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
[25]
Departments of Pediatrics and Medicine, University of California, San Francisco, San Francisco, CA, USA.
[26]
Section of Digestive Diseases, Department of Internal Medicine, and Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
[27]
Regeneron Genetics Center, Tarrytown, NY, USA.
[28]
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[29]
Department of Internal Medicine, Saint Louis University, St. Louis, MO, USA.
[30]
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
[31]
Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
[32]
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
[33]
Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
[34]
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
[35]
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
[36]
Department of Medicine, Section of Hepatology, Lewis Katz School of Medicine at Temple University, Temple University Hospital, Philadelphia, PA, USA.
[37]
Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[38]
Center for Healthcare Organization and Implementation Research, Bedford VA Healthcare System, Bedford, MA, USA.;Center for Population Health, Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA.
[39]
Phoenix VA Health Care System, Phoenix, AZ, USA.;College of Medicine, University of Arizona, Phoenix, AZ, USA.
[40]
Atlanta VA Medical Center, Decatur, GA, USA.;Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USA.
[41]
Office of Research and Development, Veterans Health Administration, Washington, DC, USA.
[42]
VA Salt Lake City Health Care System, Salt Lake City, UT, USA.;Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
[43]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.;Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
[44]
VA Boston Healthcare System, Boston, MA, USA.;Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA.
[45]
Nashville VA Medical Center, Nashville, TN, USA.;Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
[46]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[47]
Atlanta VA Medical Center, Decatur, GA, USA.;Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
[48]
VA Boston Healthcare System, Boston, MA, USA.;Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.
[49]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA.;Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
[50]
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
[51]
Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.;Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA.;Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan.
[52]
Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.;Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
[53]
Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
[54]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA.;Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
[55]
VA Salt Lake City Health Care System, Salt Lake City, UT, USA.;Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.;College of Nursing and Health Sciences, University of Massachusetts, Lowell, MA, USA.
[56]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.;Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.;Institute of Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.
[57]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. kmchang@pennmedicine.upenn.edu.;Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. kmchang@pennmedicine.upenn.edu.
[58]
主题词
丙氨酸转氨酶(Alanine Transaminase);全基因组关联研究(Genome-Wide Association Study);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);脂肪酶(Lipase);膜蛋白质类(Membrane Proteins);多态性, 单核苷酸(Polymorphism, Single Nucleotide)
DOI
10.1038/s41588-022-01078-z
PMID
35654975
发布时间
2024-12-05
- 浏览2
Nature genetics
Nature genetics
761-771页
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