Clinical Utility and Outcomes Impact of Crystal Digital PCR of Sensitizing and Resistance EGFR Mutations in Patients With Advanced Non-Small Cell Lung Cancer.

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作者： Mariona,Riudavets ^[1] ; Virginie,Lamberts ^[1] ; Damien,Vasseur ^[2] ; Edouard,Auclin ^[3] ; Mihaela,Aldea ^[1] ; Cécile,Jovelet ^[2] ; Charles,Naltet ^[1] ; Pernelle,Lavaud ^[1] ; Anas,Gazzah ^[1] ; Frank,Aboubakar ^[1] ; Miriam,Dorta ^[1] ; Jordi,Remon ^[1] ; Etienne,Rouleau ^[2] ; Maud,Ngocamus ^[4] ; Claudio,Nicotra ^[4] ; Ludovic,Lacroix ^[2] ; Benjamin,Besse ^[1] ; Laura,Mezquita ^[5] ; David,Planchard ^[1]

作者单位： Medical Oncology Department, Institut Gustave Roussy, Villejuif, France. ^[1] Medical Biology and Pathology Department, BMO unit from AMMICa UMS3655/US23, Gustave Roussy, Villejuif, France. ^[2] Medical and Thoracic Oncology Department, Hôpital Européen Georges Pompidou, Paris, France. ^[3] Early Drug Development Department, Institut Gustave Roussy, Villejuif, France. ^[4] Medical Oncology Department, Institut Gustave Roussy, Villejuif, France; Medical Oncology Department, Hospital Clínic, Barcelona, Spain; Laboratory of Translational Genomics and Targeted therapies in solid tumors, Barcelona, Spain. Electronic address: lmezquita@clinic.cat. ^[5]

关键词 Liquid biopsy NSCLC cdPCR ctDNA p.T790M resistance mutation

主题词癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);人类(Humans);肺肿瘤(Lung Neoplasms);突变(Mutation);聚合酶链反应(Polymerase Chain Reaction);前瞻性研究(Prospective Studies);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.1016/j.cllc.2022.05.010

PMID 35660356

发布时间 2022-09-23

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