Coenzyme A precursors flow from mother to zygote and from microbiome to host.

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第一作者： Yi,Yu

第一单位： Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, 9713 AV, the Netherlands.

作者： Yi,Yu ^[1] ; Marianne,van der Zwaag ^[1] ; Jouke Jan,Wedman ^[1] ; Hjalmar,Permentier ^[2] ; Niels,Plomp ^[3] ; Xiu,Jia ^[4] ; Bart,Kanon ^[1] ; Ellie,Eggens-Meijer ^[1] ; Girbe,Buist ^[3] ; Hermie,Harmsen ^[3] ; Jan,Kok ^[5] ; Joana Falcao,Salles ^[4] ; Bregje,Wertheim ^[6] ; Susan J,Hayflick ^[7] ; Erick,Strauss ^[8] ; Nicola A,Grzeschik ^[1] ; Hein,Schepers ^[9] ; Ody C M,Sibon ^[10]

作者单位： Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, 9713 AV, the Netherlands. ^[1] Interfaculty Mass Spectrometry Center, University of Groningen, 9713 AV, the Netherlands. ^[2] Department of Medical Microbiology, University Medical Center Groningen, 9700 RB, the Netherlands. ^[3] Microbial Ecology Cluster, Genomics Research in Ecology and Evolution in Nature (GREEN), Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, 9747 AG, the Netherlands. ^[4] Molecular Genetics, University of Groningen, Centre for Life Sciences, Groningen Biomolecular Sciences and Biotechnology Institute, 9747 AG, the Netherlands. ^[5] Evolutionary Genetics, Development and Behaviour (EGDB), Groningen Institute for Evolutionary Life Sciences, University of Groningen, 9747 AG, the Netherlands. ^[6] Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA. ^[7] Department of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa. ^[8] Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, 9713 AV, the Netherlands. Electronic address: h.schepers@umcg.nl. ^[9] Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, 9713 AV, the Netherlands. Electronic address: o.c.m.sibon@umcg.nl. ^[10]

关键词 Drosophila PKAN acetyl-CoA coenzyme A maternal contribution metabolism microbiome pantetheine pantothenate kinase vitamin B5