Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway.

导出原文传递

翻译打印收藏纠错

作者： Alana Gomes,de Souza ^[1] ; Iardja Stéfane,Lopes ^[2] ; Adriano José Maia Chaves,Filho ^[2] ; Talita Matias Barbosa,Cavalcante ^[2] ; João Victor Souza,Oliveira ^[2] ; Michele Albuquerque Jales,de Carvalho ^[2] ; Klistenes Alves,de Lima ^[2] ; Paloma Marinho,Jucá ^[2] ; Sabrina Silva,Mendonça ^[3] ; Melina,Mottin ^[3] ; Carolina Horta,Andrade ^[3] ; Francisca Cléa Florenço,de Sousa ^[2] ; Danielle S,Macedo ^[2] ; Marta Maria,de França Fonteles ^[2]

作者单位： Neuropharmacology Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Faculdade de Medicina, Universidade Federal do Ceará, Street: Cel. Nunes de Melo 1000, Fortaleza, Ceará, 60431-270, Brazil. alanagomesdesouza@gmail.com. ^[1] Neuropharmacology Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Faculdade de Medicina, Universidade Federal do Ceará, Street: Cel. Nunes de Melo 1000, Fortaleza, Ceará, 60431-270, Brazil. ^[2] Laboratory for Molecular Modeling and Drug Design - LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil. ^[3] Pharmacy Department, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil. ^[4]

关键词 Astrocytes Cytokines Depression Dimethyl fumarate Microglia Neurogenic inflammation