Genetically predicted vitamin K levels and risk of osteoarthritis: Mendelian randomization study.

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第一作者： Sizheng Steven,Zhao

第一单位： Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address: sizheng.zhao@manchester.ac.uk.

作者： Sizheng Steven,Zhao ^[1] ; Jonas,Bovijn ^[2] ; David M,Hughes ^[3] ; Tinting,Sha ^[4] ; Chao,Zeng ^[4] ; Houchen,Lyu ^[5]

作者单位： Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address: sizheng.zhao@manchester.ac.uk. ^[1] Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom. ^[2] Department of Health Data Science, University of Liverpool, Liverpool, United Kingdom. ^[3] Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. ^[4] Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center for Orthopedics, Sport Medicine & Rehabitation, General Hospital of Chinese PLA, Beijing, China; Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China. ^[5]

关键词 Genome-wide association study Mendelian randomization Osteoarthritis Phylloquinone Vitamin K

主题词全基因组关联研究(Genome-Wide Association Study);人类(Humans);孟德尔随机化分析(Mendelian Randomization Analysis);骨关节炎(Osteoarthritis);多态性, 单核苷酸(Polymorphism, Single Nucleotide);维生素K(Vitamin K)

DOI 10.1016/j.semarthrit.2022.152030

PMID 35667331

发布时间 2022-11-29

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