首页> Nature communications> Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.

Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.

导出 OA

翻译打印收藏纠错

第一作者： Gemma,Cadby

第一单位： School of Population and Global Health, University of Western Australia, Crawley, WA, Australia.

作者： Gemma,Cadby ^[1] ; Corey,Giles ^[2] ; Phillip E,Melton ^[3] ; Kevin,Huynh ^[2] ; Natalie A,Mellett ^[4] ; Thy,Duong ^[4] ; Anh,Nguyen ^[4] ; Michelle,Cinel ^[4] ; Alex,Smith ^[4] ; Gavriel,Olshansky ^[2] ; Tingting,Wang ^[2] ; Marta,Brozynska ^[4] ; Mike,Inouye ^[4] ; Nina S,McCarthy ^[5] ; Amir,Ariff ^[6] ; Joseph,Hung ^[7] ; Jennie,Hui ^[8] ; John,Beilby ^[8] ; Marie-Pierre,Dubé ^[9] ; Gerald F,Watts ^[10] ; Sonia,Shah ^[11] ; Naomi R,Wray ^[12] ; Wei Ling Florence,Lim ^[13] ; Pratishtha,Chatterjee ^[14] ; Ian,Martins ^[15] ; Simon M,Laws ^[16] ; Tenielle,Porter ^[16] ; Michael,Vacher ^[17] ; Ashley I,Bush ^[18] ; Christopher C,Rowe ^[19] ; Victor L,Villemagne ^[20] ; David,Ames ^[21] ; Colin L,Masters ^[18] ; Kevin,Taddei ^[15] ; Matthias,Arnold ^[22] ; Gabi,Kastenmüller ^[23] ; Kwangsik,Nho ^[24] ; Andrew J,Saykin ^[25] ; Xianlin,Han ^[26] ; Rima,Kaddurah-Daouk ^[27] ; Ralph N,Martins ^[28] ; John,Blangero ^[29] ; Peter J,Meikle ^[30] ; Eric K,Moses ^[31]

作者单位： School of Population and Global Health, University of Western Australia, Crawley, WA, Australia. ^[1] Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.;Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, VIC, Australia. ^[2] School of Population and Global Health, University of Western Australia, Crawley, WA, Australia.;Menzies Research Institute, University of Tasmania, Hobart, TAS, Australia. ^[3] Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. ^[4] School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia. ^[5] School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia. ^[6] School of Medicine, The University of Western Australia, Crawley, WA, Australia.;Department of Cardiovascular Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia.;Busselton Population Medical Research Institute Inc., Perth, WA, Australia. ^[7] Busselton Population Medical Research Institute Inc., Perth, WA, Australia.;PathWest Laboratory Medicine WA, Perth, WA, Australia. ^[8] Université de Montréal Beaulieu-Saucier Pharmacogenomics Centre, Montreal Heart Institute, Montreal, QC, Canada. ^[9] School of Medicine, The University of Western Australia, Crawley, WA, Australia.;Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Perth, WA, Australia. ^[10] Institute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia. ^[11] Institute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia.;Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia. ^[12] School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.;Cooperative research Centre (CRC) for Mental Health, Joondalup, WA, Australia. ^[13] School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.;Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.;KaRa Institute of Neurological Disease, Sydney, Macquarie Park, NSW, Australia. ^[14] School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. ^[15] Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.;Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.;Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia. ^[16] Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.;Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.;The Australian e-Health Research Centre, Health and Biosecurity, CSIRO, Floreat, WA, Australia. ^[17] The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia. ^[18] The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.;Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia. ^[19] Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia.;Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, VIC, Australia. ^[20] National Ageing Research Institute, Parkville, VIC, Australia.;University of Melbourne Academic Unit for Psychiatry of Old Age, St George's Hospital, Kew, VIC, Australia. ^[21] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.;Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. ^[22] Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. ^[23] Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.;Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA.;Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA. ^[24] Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.;Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. ^[25] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. ^[26] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.;Duke Institute of Brain Sciences, Duke University, Durham, NC, USA.;Department of Medicine, Duke University, Durham, NC, USA. ^[27] School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.;Cooperative research Centre (CRC) for Mental Health, Joondalup, WA, Australia.;Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.;KaRa Institute of Neurological Disease, Sydney, Macquarie Park, NSW, Australia. ^[28] South Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX, USA. ^[29] Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. peter.meikle@baker.edu.au.;Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, VIC, Australia. peter.meikle@baker.edu.au.;Monash University, Melbourne, VIC, Australia. peter.meikle@baker.edu.au. ^[30] Menzies Research Institute, University of Tasmania, Hobart, TAS, Australia. eric.moses@utas.edu.au.;School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia. eric.moses@utas.edu.au. ^[31]