换一批Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures.
第一作者：
Peter,Georgeson
第一单位：
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.;University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.
作者：
Peter,Georgeson [1]
;
Tabitha A,Harrison [2]
;
Bernard J,Pope [3]
;
Syed H,Zaidi [4]
;
Conghui,Qu [2]
;
Robert S,Steinfelder [2]
;
Yi,Lin [2]
;
Jihoon E,Joo [1]
;
Khalid,Mahmood [3]
;
Mark,Clendenning [1]
;
Romy,Walker [1]
;
Efrat L,Amitay [5]
;
Sonja I,Berndt [6]
;
Hermann,Brenner [7]
;
Peter T,Campbell [8]
;
Yin,Cao [9]
;
Andrew T,Chan [10]
;
Jenny,Chang-Claude [11]
;
Kimberly F,Doheny [12]
;
David A,Drew [13]
;
Jane C,Figueiredo [14]
;
Amy J,French [15]
;
Steven,Gallinger [16]
;
Marios,Giannakis [17]
;
Graham G,Giles [18]
;
Andrea,Gsur [19]
;
Marc J,Gunter [20]
;
Michael,Hoffmeister [5]
;
Li,Hsu [21]
;
Wen-Yi,Huang [6]
;
Paul,Limburg [22]
;
JoAnn E,Manson [23]
;
Victor,Moreno [24]
;
Rami,Nassir [25]
;
Jonathan A,Nowak [26]
;
Mireia,Obón-Santacana [27]
;
Shuji,Ogino [28]
;
Amanda I,Phipps [29]
;
John D,Potter [30]
;
Robert E,Schoen [31]
;
Wei,Sun [2]
;
Amanda E,Toland [32]
;
Quang M,Trinh [4]
;
Tomotaka,Ugai [33]
;
Finlay A,Macrae [34]
;
Christophe,Rosty [35]
;
Thomas J,Hudson [4]
;
Mark A,Jenkins [36]
;
Stephen N,Thibodeau [15]
;
Ingrid M,Winship [37]
;
Ulrike,Peters [29]
;
Daniel D,Buchanan [38]
作者单位：
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.;University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.
[1]
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
[2]
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.;University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.;Melbourne Bioinformatics, The University of Melbourne, Carlton, VIC, Australia.
[3]
Ontario Institute for Cancer Research, Toronto, ON, Canada.
[4]
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[5]
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
[6]
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.;German Cancer Consortium (DKTK), German Cancer Research Center(DKFZ), Heidelberg, Germany.
[7]
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
[8]
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.;Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO, USA.;Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
[9]
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
[10]
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.;University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.
[11]
Center for Inherited Disease Research (CIDR), Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[12]
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
[13]
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.;Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[14]
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
[15]
Ontario Institute for Cancer Research, Toronto, ON, Canada.;Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
[16]
Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.;Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[17]
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.;Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
[18]
Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.
[19]
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
[20]
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Department of Biostatistics, University of Washington, Seattle, WA, USA.
[21]
Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA.
[22]
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[23]
Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.;Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.;ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
[24]
Department of Pathology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
[25]
Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[26]
Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
[27]
Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Cancer Immunology Program, Dana-Farber Harvard Cancer Center, Boston, MA, USA.
[28]
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.
[29]
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Research Centre for Hauora and Health, Massey University, Wellington, New Zealand.
[30]
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
[31]
Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
[32]
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[33]
Parkville Familial Cancer Centre, Royal Melbourne Hospital, Parkville, VIC, Australia.;Colorectal Medicine and Genetics, Royal Melbourne Hospital, Parkville, VIC, Australia.;Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia.
[34]
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.;University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.;Envoi Specialist Pathologists, Brisbane, QLD, Australia.;University of Queensland, Brisbane, QLD, Australia.
[35]
University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
[36]
Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia.;Department of Medicine, The University of Melbourne, Parkville, VIC, Australia.
[37]
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia. daniel.buchanan@unimelb.edu.au.;University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia. daniel.buchanan@unimelb.edu.au.;Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia. daniel.buchanan@unimelb.edu.au.
[38]
医学主题词
结直肠肿瘤(Colorectal Neoplasms);DNA糖基化酶类(DNA Glycosylases);DNA突变分析(DNA Mutational Analysis);疾病遗传易感性(Genetic Predisposition to Disease);生殖细胞系突变(Germ-Line Mutation);杂合子(Heterozygote);人类(Humans);突变(Mutation)
DOI
10.1038/s41467-022-30916-1
PMID
35668106
发布时间
2025-05-30
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Nature communications
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